Resources: Pharmacogenetics

 

American College of Clinical Pharmacology - The Future of Medicine Pharmacogenomics Online Course

Pharmacogenomics and Personalized Medicine This CME introduces pharmacogenomics and the influence of a patient's genetic background on drug response. The course was developed by the AMA and the Food and Drug Administration, and is designed for physicians who have had little exposure to the topic in clinical practice or who want a better understanding of the topic.

Medicine For You Information from the National Institute of Health that explains pharamcogenetics in laymans terms.

Pharmacogenomics as explained by the Human Genome Project.

Pharmacogenomics as explained by the American Medical Association.

Preventable Adverse Drug Reactions: A Focus on Drug Interactions
A learning module developed by the Center for Education and Research on Therapeutics (CERT) in collaboration with the Center for Drug Evaluation and Research at the Food and Drug Administration.

PharmGKB - The Pharmacogenetics and Pharmcogenomics Knowledge Base

Pharmacogenetics Research Network at National Institute of General Medical Sciences (NIGMS)

The Merck Manual, Sec.22 Ch.301 Topics: Pharmacogenetics

Cancer Patients at Risk of Drug Interactions: Drugs for Conditions Other Than Cancer Most Often Involved
More than a quarter of cancer patients may be at risk of potentially serious drug interactions, according to a recent study in the Journal of the National Cancer Institute. However, chemotherapy agents were not the primary culprit, the team from Princess Margaret Hospital in Toronto, Canada, reports.

Clinical Guidelines for Psychiatrists for the Use of Pharmacogenetic Testing for CYP450 2D6 and CYP450 2C19
De Leon, J. et al. Psychosomatics 47:1 75-85 (2006).

Drug-metabolizing enzymes: Evidence for clinical utility of pharmacogenetic tests
Anderson T. et al. Clinical Pharmacology & Therapeutics, 78:6 559-581 (2005).

Cancer pharmacogenomics: current and future applications Watters JW, McLeod HL Biochim Biophys Acta 2003 Mar 17;1603(2):99-111

Pharmacogenomics study of statin therapy and cholesterol reduction
Chasman DI, et al.
JAMA 2004; 291(23) 2821-2827.

Role of pharmacogenomics in individualising treatment with SSRIs
Mancama D, Kerwin RW
CNS Drugs 2003;17(3):143-51

Cardiovascular pharmacogenomics: current status, future prospects
Anderson JL, Carlquist JF, Horne BD, Muhlestein JB
J Cardiovasc Pharmacol Ther 2003;8(1):71-83

Pharmacogenomics — Drug disposition, drug targets, and side effects
Evans, WE, and McLeod, HL
NEJM 2003; 348:538-549

Pharmacogenetics anticancer agents research group

Pharmacogenetics at American Medical Association Website Pharmacogenetics Holds Promise of Personalized Medicine, May also help predict and avoid drug reactions.

FPReport article: Pharmacogenetics should help clinicians individualize drug therapies

Inheritance and Drug Response, New England Journal of Medicine

The Dosing of Atypical Antipsychotics, Psychosomatics

Genes and Drug Response, New England Journal of Medicine

Genomic Medicine - A Primer, New England Journal of Medicine

Pharmacogenomics -Drug Disposition, Drug Targets, and Side Effects, New England Journal of Medicine

Pharmacogenomics: Bench to Bedside, Nature

Cytochrome P450 Table of Drugs with links to PubMed Articles

The Cytochrome P-450 Enzyme System by Edmund M. Hayes, Pharm. D.

Cytochrome P450 Enzymes and Psychopharmacology by Sheldon H. Preskorn, M.D. and Anne T. Harvey, Ph.D.

Antidepressant Drug Interactions in the Elderly by Roger J. Cadieux, MD. Understanding the P-450 system is half the battle in reducing risks.

Application of Pharmacogenomics in Clinical Pharmacology, Toxicology Mechanisms and Methods