TABLE OF COMMONLY USED DRUGS:
ARRANGED AS P450 CYTOCHROME SUBSTRATES,
INDUCERS AND INHIBITORS
Genelex currently offers DNA Prescription Drug Reaction Profiles that test 2D6, 2C9, 1A2 and 2C19 functionality. The table below lists many commonly prescribed drugs that are metabolized through these and other pathways in the Cytochrome P-450 system. This is an abridged chart and not all pathways may be listed for all medications. If your medication is not on the list, or to obtain the most thorough information on drug metabolism, enter the medication into www.genemedrx.com.
WE EXPECT OUR CLIENTS TO SEEK PROFESSIONAL ADVICE CONCERNING ANY MEDICAL OR LEGAL ACTIONS THAT MIGHT BE SUGGESTED BY THE INFORMATION WE OFFER. Do not alter the dosage amount or schedule of any drug you are taking without first consulting your medical provider or pharmacist.
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Adverse Drug Reaction Standard
Panel
2D6, 2C9, and 2C19
Price: $600.00 
Adverse Drug Reaction Extended Panel
2D6, 2C9, 2C19, 1A2, and NAT2
Price: $1000.00
| Substrates | |||||
| CYP1A2 | CYP2B6 | CYP2C19 | CYP2C9 | CYP2D6 | CYP3A4/5/7 |
| Psychotropics | bupropion | Psychotropics | Psychotropics | Psychotropics | Psychotropics |
| amitriptyline | cyclophosphamide (p) | amitriptyline | fluoxetine | amphetamines | alprazolam |
| chlorpromazine | efavrinez <Sustiva> |
citalopram | (sertraline) | amitriptyline | amitriptyline |
| clomipramine | ifosphamide (p) | clomipramine | valproic acid | aripiprazole | aripiprazole |
| clozapine | ketamine | diazepam | atomoxetine | buspirone | |
| duloxetine | meperidine | escitalopram | NSAIDS | benztropine | carbamazepine |
| fluphenazine | methadone | flunitrazapam | aceclofenac | chlorpromazine | citalopram |
| fluvoxamine | (nicotine) | (fluoxetine) | celecoxib | (citalopram) | (clomipramine) |
| imipramine | propofol | imipramine | diclofenac | clomipramine | (clozapine) |
| melatonin | sertraline | moclobemide | flurbiprofen | desipramine | (diazepam) |
| (mirtazapine) | selegiline | sertraline | ibuprofen | doxepin | estazolam |
| (olanzapine) | (tamoxifen) | trimipramine | indomethacin | duloxetine | eszopiclone <Lunesta> |
| perphenazine | testosterone | lornoxicam | fluoxetine | fluoxetine | |
| propafenone | Anticonvulsants | meloxicam | fluvoxamine | haloperidol | |
| (propranolol) | mephenytoin | (naproxen) | haloperidol | midazolam | |
| ramelteon <Rozerem> |
phenytoin | piroxicam | imipramine | nefazodone | |
| thioridazine | suprofen | mirtazapine | pimozide | ||
| thiothixene | tenoxicam | nortripyline | quetiapine | ||
| trifluoperazine | Proton Pump Inhibitors | paroxetine | risperidone | ||
| (esomeprazole) | Hypoglycemics | perphenazine | (sertraline) | ||
| Others | lansoprazole | chlorpropamide | risperidone | trazodone | |
| anagrelide | omeprazole | glipizide <Glucotrol> |
(sertraline) | triazolam | |
| caffeine | (pantoprazole) | glimepiride <Amaryl> |
thioridazine | zaleplon <Sonata> |
|
| cinacalcet | glyburide <DiaBeta> |
venlafaxine | (ziprasidone) | ||
| cyclobenzaprine <Flexeril> |
nateglinide <Starlix> |
zolpidem <Ambien> |
|||
| dacarbazine | Others | (rosiglitazone <Avandia> |
Others | ||
| erlotinib | carisoprodol <Soma> |
tolbutamide <Orinase> |
Antihistamines | Drugs of abuse/treatment | |
| flutamide | cilostazol | chlorpheniramine | buprenorphine | ||
| frovatriptin | cyclophosphophamide (p) | Others | diphenhydramine | cocaine | |
| lidocaine | ifosphosphamide (p) | bosentan | hydroxyzine <Atarax> |
fentanyl | |
| mexiletine | nelfinavir | candesartan <Atacand> |
Beta Blockers | ketamine | |
| naproxen | proguanil |
fluvastatin <Lescol> |
carveodilol | methadone | |
| ondansetron | propranolol | irbesartan | metoprolol | oxycodone | |
| (phenacetin) | R-warfarin | losartan |
propranolol | phencyclidine <PCP> |
|
| R-warfarin | tolbutamide | phenobarbital | timolol | Antibiotics/Antifungals | |
| propranolol | voriconazole | phenytoin | Cough Medicines | macrolides (not azithromycin) | |
| R-warfarin | sulfa drugs | dolesetron(p) | itraconazole | ||
| riluzole <Rilutek> |
(tamoxifen) | doxorubicin | ketoconazole | ||
| ropinirole | S-warfarin | encainide | telithromycin <Ketek> |
||
| ropivaciane <Naropin> | tetrahydrocannabinol (mj) | Anticonvulsants | |||
| tacrine <Cognex> |
torsemide <Tomide> |
MDMA <ecstasy> |
carbamazepine | ||
| theophylline | metoclopramide <Reglan> |
ethosuximide | |||
| tizanidine <Zanaflex> |
mexiletine | felbamate | |||
| zileutin <Zyflo> |
Opiates | tiagabine <Gabitril> |
|||
| zolmitriptan <Zomig> |
codeine(p) | zonisamide <Zonegran> |
|||
| hydrocodone (p) | Antihistamines | ||||
| (oxycodone) | desloratadine <Clarinex> |
||||
| tramadol | fexofenadine <Allegra> |
||||
| loratadine <Claritin> |
|||||
| phenacetin | Asthma Medication | ||||
| proprafenone <Rythmol> |
fluticasone <Flovent> |
||||
| (ranitidine |
salmeterol <Serevent> |
||||
| tamoxifen(p) | zileuton <Zyflo> |
||||
| tolterodine <Detrol> |
Calcium Channel Blockers | ||||
| tropisetron | Hormones/chemotherapeutics | ||||
| cortisols | |||||
| desogestrel (p) | |||||
| ethinyl estradiol <OCs> |
|||||
| progestins /progesterone | |||||
| vincristine and others | |||||
| Others | |||||
| aprepitant <Emend> |
|||||
| esomeprazole | |||||
| granisetron | |||||
| nateglinide <Starlix> |
|||||
| omeprazole | |||||
| pioglitazone <Actos> |
|||||
| quinidine | |||||
| sildenafil | |||||
| Statins, (ator, lov, sim) | |||||
| tolterodine <Detrol> |
|||||
| Inhibitors | |||||
| CYP1A2 | CYP2B6 | CYP2C19 | CYP2C9 | CYP2D6 | CYP3A4/5/7 |
| acyclovir | clopidogrel <Plavix> |
artemisinin | amiodarone | amiodarone | amiodarone |
| amiodarone | efavirenz | chloramphenicol | anastrazole | (amitriptyline) | amprenavir |
| caffeine | fluoxetine | delavirdine | cimetidine | bupropion | aprepitant (initially) |
| cimetidine | fluvoxamine | efavirenz | delavirdine | celecoxib | atazanavir <Reyataz> |
| ciprofloxacin | ketoconazole | esomeprazole | efavirenz | chlorpheniramine | (cimetidine) |
| enoxacin | memantine | felbamate | fenofibrate <Tricor> |
chlorpromazine | ciprofloxacin |
| echinacea | nelfinavir | (fluconazole) | fluconazole | cimetidine | clarithromycin |
| famotidine | oral contraceptives | (fluoxetine) | (fluoxetine) | (citalopram) | delavirdine |
| flutamide | paroxetine | fluvoxamine | fluvoxamine | chlorpheniramine | diltiazem |
| fluvoxamine | ritonavir | indomethacin | fluvastatin | clomipramine | doxycycline |
| grapefruit juice | thiotepa | inh | isoniazid | (desipramine) | echinacea |
| lidocaine | ticlopidine <Ticlid> |
modafinil <Provigil> |
ketoconazole | diphenhydramine | enoxacin |
| lomefloxacin | omeprazole <Prilosec> |
leflunomide | doxepin | erythromycin | |
| mexiletine <Mexitil> |
oral contraceptives | phenylbutazone | duloxetine | fluconazole | |
| moclobemide | oxcarbazepine | (sertraline) | (fluvoxamine) | fluvoxamine | |
| norfloxacin | ticlopidine | sulfamethoxazole | fluoxetine | grapefruit juice | |
| ofloxacin | topiramate | sulfaphenazole | halofantrine | indinavir | |
| oral contraceptives | voriconazole | tamoxifen | haloperidol | itraconazole | |
| perphenazine | teniposide | (hydroxyzine) | ketoconazole | ||
| phenacetin | valproic acid | imipramine | miconazole | ||
| propafenone | voriconazole <Vfend> |
methadone | nefazodone | ||
| ropinirole | (zafirlukast, <Accolate>) |
metoclopramide | nelfinavir | ||
| tacrine | 5-fluorouracil | moclobemide | ritonavir in all forms | ||
| ticlopidine | paroxetine | saquinavir | |||
| tocainide | pimozide | Star fruit | |||
| verapamil | propafenone | telithromycin | |||
| zileuton |
quinidine/quinine | verapamil | |||
| ritonavir | voriconazole | ||||
| (sertraline) | |||||
| terbinafine | |||||
| thioridazine | |||||
| ticlopidine | |||||
| Inducers | |||||
| carbamazepine | lopinavir/ritonavir | ginko biloba | aprepitant-long term | dexamethasone | aprepitant (long term) |
| charbroiled meat | phenobarbital | rifampin | barbituates | rifampin | barbituates |
| cigarette smoke | phenytoin | st johns wort | bosentan | bosanten | |
| cruciferous veggies | rifampin | carbamazepine | carbamazepine | ||
| esomeprazole | rifampin-chronic | efavirenz | |||
| griseofulvin | ritonavir and boosted Pis | felbamate | |||
| insulin | St Johns wort-long term | glucocorticoids | |||
| lansprazole | modafinil | ||||
| marijuana smoke | nafcillin | ||||
| moricizine | nevirapine | ||||
| omeprazole | (oxcarbazepine) | ||||
| rifampin | phenytoin | ||||
| ritonavir | primidone | ||||
| rifampins | |||||
| St Johns Wort | |||||
| pioglitazone <Actos> |
|||||
| topiramate at >200 mg/d | |||||
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