Other Resources
Warfarin-specific Pharmacogenetics
Pharmacogenomics and Personalized Medicine This CME introduces pharmacogenomics and the influence of a patient's genetic background on drug response. The course was developed by the AMA and the Food and Drug Administration, and is designed for physicians who have had little exposure to the topic in clinical practice or who want a better understanding of the topic.
Medicine For You Information from the National Institute of Health that explains pharamcogenetics in laymans terms.
Pharmacogenomics as explained by the Human Genome Project.
Pharmacogenomics as explained by the American Medical Association.
Preventable
Adverse Drug Reactions: A Focus on Drug Interactions
A learning module developed by the Center for Education and Research on Therapeutics
(CERT) in collaboration with the Center for Drug Evaluation and Research at
the Food and Drug Administration.
PharmGKB
- The Pharmacogenetics and Pharmcogenomics Knowledge Base
Pharmacogenetics
Research Network at National Institute of General Medical Sciences (NIGMS)
The
Merck Manual, Sec.22 Ch.301 Topics: Pharmacogenetics
Cancer
Patients at Risk of Drug Interactions: Drugs for Conditions Other Than Cancer
Most Often Involved
More than a quarter of cancer patients may be at risk of potentially serious
drug interactions, according to a recent study in the Journal of the National
Cancer Institute. However, chemotherapy agents were not the primary culprit,
the team from Princess Margaret Hospital in Toronto, Canada, reports.
Clinical
Guidelines for Psychiatrists for the Use of Pharmacogenetic Testing for CYP450
2D6 and CYP450 2C19
De Leon, J. et al. Psychosomatics 47:1 75-85 (2006).
Drug-metabolizing
enzymes: Evidence for clinical utility of pharmacogenetic tests
Anderson T. et al. Clinical Pharmacology & Therapeutics, 78:6 559-581 (2005).
Cancer pharmacogenomics: current and future applications Watters JW, McLeod HL Biochim Biophys Acta 2003 Mar 17;1603(2):99-111
Pharmacogenomics
study of statin therapy and cholesterol reduction
Chasman DI, et al.
JAMA 2004; 291(23) 2821-2827.
Role
of pharmacogenomics in individualising treatment with SSRIs
Mancama D, Kerwin RW
CNS Drugs 2003;17(3):143-51
Cardiovascular
pharmacogenomics: current status, future prospects
Anderson JL, Carlquist JF, Horne BD, Muhlestein JB
J Cardiovasc Pharmacol Ther 2003;8(1):71-83
Pharmacogenomics
— Drug disposition, drug targets, and side effects
Evans, WE, and McLeod, HL
NEJM 2003; 348:538-549
Pharmacogenetics
anticancer agents research group
Pharmacogenetics at American Medical Association Website Pharmacogenetics
Holds Promise of Personalized Medicine, May also help predict and avoid drug
reactions.
FPReport article: Pharmacogenetics should help clinicians individualize drug therapies
Inheritance and Drug Response, New England Journal of Medicine
The
Dosing of Atypical Antipsychotics, Psychosomatics
Genes and Drug Response, New England Journal of Medicine
Genomic Medicine - A Primer, New England Journal of Medicine
Pharmacogenomics -Drug Disposition, Drug Targets, and Side Effects, New England Journal of Medicine
Pharmacogenomics: Bench to Bedside, Nature
Cytochrome
P450 Table of Drugs with links to PubMed Articles
The Cytochrome P-450 Enzyme System by Edmund M. Hayes, Pharm. D.
by Sheldon H. Preskorn, M.D. and Anne T. Harvey, Ph.D.
Antidepressant Drug Interactions in the Elderly by Roger J. Cadieux, MD. Understanding the P-450 system is half the battle in reducing risks.
Application
of Pharmacogenomics in Clinical Pharmacology, Toxicology Mechanisms and Methods
Metabolic Polymorphisms and Susceptibility to Cancer. Edited by P. Vineis, et al, International Agency for Research on Cancer Scientific Publication No. 148, 1999. ISBN: 92 832 2148 6
This multi-author, advanced textbook is a highly cohesive review of the metabolic systems responsible for metabolizing most of the toxins and drugs that we come in contact with in our diet and in the atmosphere. While the focus is on environmental carcinogenesis, pharmacogeneticists will recognize the systems that are described as the DMEs or drug metabolizing enzymes in the extensively referenced chapters. The beginning chapters cover the basics of phenotyping and genotyping xenobiotics; and carcinogen metabolism and the methods, strategies, and pitfalls of genetic epidemiology study design are discussed. The important CYP (cytochrome p-450) NAT (N-acetyltransferase), and GST (glutathione S-transferase) isoenzymes are discussed in detail in several chapters. The book finishes with an extensive meta-analysis appendix of association studies. The index could be more comprehensive and the figures and appendix more clearly labeled, but these are nits when compared to the scope and readability of this up-to-date review of this extremely important and dynamic field.
Detection of New Adverse Drug Reactions. Dr. MDB Stephens, Professor P.A. Routledge & Dr. J.C.C. Talbot. Macmillan Scientific: New York. 1998. ISBN: 0-333-69391-4
Warfarin-specific Pharmacogenetics
NPR story "Genetic Testing Can Help with Drug Dosages"
WarfarinDosing.org
A free Web site to help doctors and other clinicians begin warfarin therapy
by estimating the therapeutic dose in patients new to warfarin.
Health
Care Savings from Personalizing Medicine Using Genetic Testing: The Case of
Warfarin
Working paper from AEI-Brookings Joint Center that estimates that formally integrating
genetic testing into routine warfarin therapy could allow American warfarin
users to avoid 85,000 serious bleeding events and 17,000 strokes annually. We
estimate the reduced health care spending from integrating genetic testing into
warfarin therapy to be $1.1 billion annually, with a range of about $100 million
to $2 billion.
Feed Your
Genes Right
Eat to Turn Off Disease-Causing Genes and Slow Down Aging (published by John
Wiley and Sons, 2005) describes in simple and understandable terms exactly how
our genes depend on good nutrition and adequate amounts of certain vitamins
and minerals.
Newsweek - It isn't just what you eat that can kill you,
and it isn't just your DNA that can save you-it's how they interact.
Nutrigenomics.UCDavis.edu - a website dedicated to promoting the new science of nutritional genomics.
NuGO
is a world-leading network integrating nutritional genomics in Europe. Nutrition
and health research is focused on the prevention of disease.
Cambridge Genetics Knowledge Park You are what you eat? The promise of nutrigenetics
and nutrigenomics
The Seven
Daughters of Eve
by Bryan Sykes
The Science That Reveals Our Genetic Ancestry
Journey
of Man: A Genetic Odyssey
by Spencer Wells
How Interpret Your DNA Test Results for Family History or Ancestry
Prehistoric migrations from modern human DNA
DNA Consulting is a commercial Internet service for individuals interested in pursuing the historical and anthropological interpretation of DNA tests.
The Human Genome Project (HGP) has finished its initial sequencing of the 3 billion letters in the human genome. The ultimate goal of this massive, global effort is to develop new ways to detect, treat, cure, and prevent the thousands of diseases that afflict the world. The HGP will have more impact on civilization than any other project in history. Their site reflects this wealth and potential and is the finest source of links to other resources on the Web.
The American Association for the Advancement of Science has a profusely illustrated online book, Your Genes, Your Choices, using different real-life scenarios to introduce genetics and the choices posed by genetic tests. Also available in print with a companion video.
provides public health professionals and others with current information on the impact of human genetic research and gene discoveries on disease prevention and health promotion. Excellent review of scientific literature reporting on discoveries of genetic variants, related disease outcomes, and the complex social, legal, and ethical issues surrounding genetic discoveries.
were produced by National Public Radio with a grant from the National Science Foundation. John Hockenberry hosts nine one-hour programs on the world of genetics. Learn the stories of real people whose lives have been changed in ways that seemed unimaginable only a few years ago. Understand the science and the decisions we face as experts and public watchdogs explore the issues. The site hosts an interactive bulletin board on Marfan Syndrome, breast cancer, and other genetics-related subjects. It also has one of the Web's best resource guides to genetics research.
GeneEd is the leading provider of e-Learning solutions for life science, combining advanced web technologies, creative design, and educational skills into a rich learning experience. Especially if you are a professional wishing to broaden or deepen your understanding of genetics, GeneEd has virtual courses and other options to help you and an excellent genetics glossary.
Genomics: A Global Resource offers superior coverage of news in genomics; thorough coverage of journals, magazines, and periodicals; and the Web's best review of state, national, and global genomics-related legislation and legal issues.
is a good source of biotechnology industry information, news, book reviews,
chats, and forums. It also has a related site on genetics.
Genome: The Autobiography of a Species in 23 Chapters by Matt Ridley. Harper Collins, ISBN 0-06-019497-9.
Genome is natural, human and science history, but most of all it is human biology with a big "B." Science editor and reporter Matt Ridley takes on life-size issues like, immortality, free will, instinct, personality and politics, and puts them into a genetic context based on the 23 chromosomes. You know this is working when you get to X and Y, the sex chromosomes and find that conflict, what else, is the topic. Well researched, intelligently written and full of stories and quotes that illustrate genomic science with all the vibrance and life that it deserves.
A-Z Guide to Drug-Herb-Vitamin Interactions edited by Schulyer W. Lininger. Prima Heath, 1999, ISBN
When your body is exposed to chemicals, natural or not, it has no way to tell whether they came from a prescription drug, an herbal remedy, or an everyday food. Whether it be licorice, ginseng or Prozac these substances have powerful pharmacological effects, and just like prescription medicines they may interact inside your body - sometimes to good effect, sometimes producing an adverse drug reaction. The A-Z guide to drug-herb-vitamin interactions is a comprehensive guide to what is known about the interactions between these substances. The alphabetical listings of commonly used, approved drugs include a sentence or two about the drug followed by specific information on its interactions with dietary supplements, herbs, foods and other compounds. Separate appendices list the ingredients in many over-the-counter drugs, drug interactions, and drugs by Pharmacist Classification. The hundreds of references organized by drug, are a comprehensive entre to the medical literature. At $19.95 this is one of the most cost-effective medical books you can own. It is bound to be an invaluable resource for those involved with complementary and integrative medicine.
Health-Sites-Directory.com
Health Services Web Directory
Health
Diseases - Conditions and Ailments
Health-Diseases.org contains lot of information about the causes, symptoms and
treatment of many common diseases, conditions and ailments. Also there are many
prevention tips given on our site to prevent those diseases from occuring in
future.
 Disclaimer
The content of this web site is for public use, free of charge, and for information only. It is not intended to be used in any other way. The authors disclaim any liability, loss, injury, or damage incurred as a consequence, directly or indirectly, of the use and application of any of the content of this web site.
The information presented on this site is intended
as general health information and as an educational tool. It is not intended
as medical advice. Only a physician, pharmacist, or other healthcare professional
should advise a patient on medical issues and should do so using a medical
history and other factors identified and documented as part of the health
professional/patient relationship. |
| Home | Drug Reaction Testing | Nutritional Genetics Ancestry DNA Testing | Predictive Genetics | How to Order Other Resources | DNA Newsroom | Privacy & Ethics About Genelex | Careers | Contact Us | DNA Newsroom |
|
Founded in 1987, Genelex Corporation has been accredited by the AABB Parentage Testing Committee in DNA parentage testing since 1992, is Washington State Medical Test Site No. MTS-3919 CLIA No. 50D0980559, and has contributed to the validation of National Institute of Standards and Technology (NIST) Standard Reference Materials. 3000 First Ave. Ste. One Seattle, WA 98121 Site Created by Narayan
design |
