Tamoxitest for Tamoxifen Resistance
Genelex will be happy to mail information to you or to your healthcare provider on your behalf, simply complete the request form.
Is your physician thinking of prescribing Tamoxifen?
Are you currently taking Tamoxifen?
Are you concerned about drug effectiveness?
If you answered yes to any of these questions, please download this physician information package so you can discuss Tamoxitest tamoxifen resistance testing (Cytochrome P450 2D6 - CYP2D6) with your healthcare provider. For more information on testing benefits, click here.
I recovered from ER (estrogen receptor) positive breast cancer and was prescribed tamoxifen to prevent the cancer from coming back. I wanted to do everything possible to make sure that my treatment was successful ...
+ Click here to read Susan's story
Click here to see what Dr. Susan Love, a respected authority on breast cancer, has to say about tamoxifen DNA testing.
Genelex will be happy to mail information to you or to your healthcare provider on your behalf, simply complete the request form.
Tamoxifen is a medication for the treatment of breast cancer
or for people at a high risk of developing breast cancer.
Recent research has shown that 7-10% of women with breast cancer
may not receive the full medical benefit from taking tamoxifen
due to their unique genetic make-up. These women have a version
of a gene called Cytochrome P450 2D6, which reduces the effectiveness
of tamoxifen and increase their chance of breast cancer recurrence.
The evidence is so strong that an FDA panel recently recommended
that the label of tamoxifen be changed to say that 2D6 poor metabolizers
who take tamoxifen have a higher risk for breast cancer recurrence,
and that testing is available.( Click here to download tamoxifen 2D6 testing information for your healthcare provider).
DNA Drug Sensitivity Testing™ can examine your DNA variations in
2D6 and other important drug processing pathways. Your physician
can use this information to adjust dosage and select medications
that will be the safest and most effective for you. Since more
than 20% of all clinically used medications are metabolized by
2D6, knowing your 2D6 status can help you and your doctor with
the future selection of medications.
Genetic testing can tell whether tamoxifen is likely to be an
effective treatment for you. This test looks at a specific gene,
called 2D6, to determine whether your body can fully metabolize
tamoxifen to its active form, endoxifen. If tamoxifen is not an effective treatment, your physician may recommend aromatase inhibitors.
Who Should Be Tested
The CYP2D6 test for tamoxifen is considered appropriate for women
who are taking or considering taking tamoxifen to prevent the
recurrence of breast cancer. It is especially important if
the patient is also taking or considering co-administration
with SSRIs.
The Testing Process
The process is simple. You can order testing directly if you have a physician prescription or your healthcare provider can request testing for you. We send a cheek swab collection kit with directions by mail. Samples are submitted using the enclosed return mailer and results are provided in ten days or less. Faster testing is available for an additional charge. Call a DNA testing consultant at (800) 523-3080 for details and to order, or request information to you or to your healthcare provider on your behalf, simply complete the request form.
References
Oesterheld, Jessica, M.D. GeneMedRx Drug Metabolism Tables
Werner Schroth; Matthew P. Goetz; Ute Hamann; et al. Association Between CYP2D6 Polymorphisms and Outcomes Among Women With Early Stage Breast Cancer Treated With tamoxifen JAMA. 2009;302(13):1429-1436
Goetz MP et al. The impact of Cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen. Breast Cancer Res Treat 2007; 101 (1): 113-21
Borges S et al. Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: implication for optimization of breast cancer treatment. Clin Pharmacol Ther 2006;80(1):61-74
Note: Testing requires a prescription from a physician.
Disclaimer: Do not alter the dosage amount or schedule of any drug you are taking without first consulting a qualified healthcare professional.
The text presented on this page is not a substitute for professional medical advice. It is for your information only and may not represent your true individual medical situation. Do not hesitate to consult your healthcare provider if you have any questions or concerns.
Unless provided information expressly states that is was created by an MD or PharmD or cites another specific source, it was authored by Genelex employees that are not healthcare providers.
By Kristine Ashcraft, B.S. Last Reviewed 8/2/2010
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